The CGI-animated series chronicled the continuing comic saga of five misfits who lived, worked and played on the starship Jupiter 42, which was controlled by a neurotic A.I. known as Spaceship Bob. Bob's neuroses were kept in check by the verbally abusive pilot T'Nuk, and the ship's inner workings were tended by Gus, the depressive robotic chief engineer. It is unclear what job, if any, was performed by teen slacker Whip, but everyone knew what kinds of jobs sexy android Six specialized in.

The captain, a walking purple blob of rancor named Chode, hated his crew and they hated him back, but they had bigger problems to worry about - namely, the corporate-minded Dark Clowns, who were bent on dominating the galaxy, and the hopelessly conformist Confederation, which would stop at nothing to bring the bumbling antiheroes to injustice.

The Dark Clowns and the Confederation, despite being more alike than different, clashed constantly in their cold war to determine whose brand of oppression would dominate the universe. Each insisted the other was the cause of all problems great and small, and their power struggle was basically a huge pain in the ass for sentient beings everywhere.